Robust super-structured porous hydrogel enables bioadaptive repair of dynamic soft tissue.

ABSTRACT: Well-orchestrated integration of multiple contradictory properties into a single material is crucial for dynamic soft tissue defect repair but remains challenging. Bioinspired by diaphragm, we have successfully developed a robust super-structured porous hydrogel with anisotropic skeleton and asymmetric porous surfaces via integrated molding. Thanks to synergistic toughening of anisotropic structure and Hofmeister effect of amino acid, our hydrogel achieves high tensile strength (22.2 MPa) and elastic modulus (32.4 MPa) for strong mechanical support, while maintaining excellent toughness (61.9 MJ m^-3) and fatigue threshold (5.6 kJ m^-2) against dynamic stretching during the early healing phase. The mechanical properties of hydrogel gradually decrease during the late hea

SUBMITTER: He S 

PROVIDER: S-EPMC11968947 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature