Preclinical assessment of anti-arthritic activity of methanolic extract from processed Plumbago zeylanica roots.

ABSTRACT: Ayurveda, a traditional Indian system of medicine, advocates the use of processed Plumbago zeylanica L. roots for managing inflammatory and rheumatic conditions. However, scientific evidence supporting its anti-arthritic potential remains unexplored. Our preliminary in vitro and in silico studies demonstrated potent anti-inflammatory activities in the methanolic extract of the processed root. Hence, this study aimed to investigate the pharmacological activities of the methanolic extract of processed roots in Freund's Complete Adjuvant (FCA)-induced rheumatoid arthritis in rats. Rheumatoid arthritis was induced in the rats by intra-articular injection of FCA in right paw on day 0, and treatment of prednisolone and different doses of Plumbago zeylanica methanolic extract (PZME) was given fro

SUBMITTER: Das T 

PROVIDER: S-EPMC11969016 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature