Histidine-rich glycoprotein inhibits TNF-α-induced tube formation in human vascular endothelial cells.

ABSTRACT:

Introduction

Tumor necrosis factor-α (TNF-α)-induced angiogenesis plays a critical role in tumor progression and metastasis, making it an important therapeutic target in cancer treatment. Suppressing angiogenesis can effectively limit tumor growth and metastasis. However, despite advancements in understanding angiogenic pathways, effective strategies to inhibit TNF-α-mediated angiogenesis remain limited.

Methods

This study investigates the antiangiogenic effects of histidine-rich glycoprotein (HRG), a multifunctional plasma protein with potent antiangiogenic properties, on TNF-α-stimulated human endothelial cells (EA.hy926). Tube formation assays were performed to assess angiogenesis, and gene/protein expression analyses were conducted to evaluate HRG's effects on integrins

SUBMITTER: Hatipoglu OF 

PROVIDER: S-EPMC11969118 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature