Familial cardiac laminopathy with predominant atrial involvement: a case series of a family with <i>LMNA</i> mutation.

ABSTRACT:

Background

We present a case series detailing a family with familial cardiac laminopathy, including the female index patient, her father, her brother, and her daughter, all diagnosed with atrial arrhythmias, i.e. atrial fibrillation (AF), atrial flutter, and atrial premature contractions.

Case summary

The index patient is known for frequent premature atrial contractions since the age of 35 years and for persistent AF since the age of 46 years. Rhythm control of symptomatic AF was achieved after two ablations. The brother of the index patient is known for asymptomatic persistent AF since the age of 26 years. He has opted for rate control and oral anticoagulation. Their father had persistent AF for many years before his death. The daughter of the index patient has asymptomatic

SUBMITTER: Mussigbrodt A 

PROVIDER: S-EPMC11969145 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature