C3 glomerulopathy in children: experience at a resource-limited center.

ABSTRACT:

Background

In children, C3 glomerulopathy (C3G) is a heterogeneous disease characterized by diverse clinicopathological profiles and kidney outcomes. However, diagnostic work-up in resource-limited settings is challenging because of the unavailability of complement assays and limited access to electron microscopy or genetic testing.

Purpose

This study aimed to describe the clinicopathological features and response to immunosuppression and evaluate renal outcomes among children with C3G in a resource-limited setting.

Methods

This retrospective cohort study involved a review of the hospital records of 46 children (2013-2021) diagnosed with C3G on kidney biopsy. Their clinical, laboratory, treatment, and outcome details at onset and follow-up were noted.

Results

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SUBMITTER: Reddy S 

PROVIDER: S-EPMC11969206 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature