Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer.

ABSTRACT: Cancer has been characterized as a wound that does not heal. Malignant cells are morphologically distinct from normal proliferating cells but have extensive similarities to tissues undergoing wound healing and/or regeneration. The mechanistic basis of this similarity has, however, remained enigmatic. Here, we show that the genomic region upstream of Myc, which carries more cancer susceptibility in humans than any other genomic region, is required for intestinal regeneration after radiation damage. Failure to regenerate is associated with inefficient Ly6a/Sca1⁺ stem/progenitor cell mobilization, and almost complete failure to re-establish Lgr5+ cell compartment in the intestinal crypts. The Myc upstream region is also critical for growth of adult intestinal c

SUBMITTER: Sur I 

PROVIDER: S-EPMC11969384 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature