The impact of a low-carbohydrate (vs. low-fat) diet on fat mass loss in African American women is modulated by insulin sensitivity.

ABSTRACT:

Objective

The objective of this study was to examine the independent and interactive effects of insulin sensitivity (S_I), the acute insulin response to glucose, and diet on changes in fat mass (FM), resting and total energy expenditure (REE and TEE, respectively), and mechanical efficiency, during weight loss, in African American women with obesity.

Methods

A total of 69 women were randomized to low-fat (55% carbohydrate [CHO], 20% fat) or low-CHO (20% CHO, 55% fat) hypocaloric diets for 10 weeks, followed by a 4-week weight-stabilization period (controlled feeding). S_I and acute insulin response to glucose were measured at baseline with an intravenous glucose tolerance test; body composition was measured with bioimpedance analysis at baseline and week

SUBMITTER: Martins C 

PROVIDER: S-EPMC11969443 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature