<i>Withania somnifera</i> root extract (LongeFera^™) confers beneficial effects on health and lifespan of the model worm <i>Caenorhabditis legans</i>.

ABSTRACT:

Background

Withania somnifera is among the most widely prescribed medicinal plants in traditional Indian medicine. Hydroalcoholic extract of the roots of this plant was investigated for its effects on the overall health and lifespan of the model worm Caenorhabditis elegans.

Methods

The extract's effect on worm lifespan and fertility was observed microscopically. Worm motility was quantified through an automated worm tracker. The metabolic activity of the worms was captured using the Alamar Blue® assay. Differential gene expression in extract-treated worms was revealed through a whole transcriptome approach.

Results

Extract-exposed gnotobiotic worms, in the absence of any bacterial food, registered longer lifespan, higher fertility, better motility, and m

SUBMITTER: Thakkar N 

PROVIDER: S-EPMC11969495 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature