Causal associations between blood metabolites and breast cancer.

ABSTRACT:

Introduction

The associations between blood metabolites and breast cancer remain unclear. We conducted a systematic two-sample Mendelian randomization (MR) analysis to identify key human blood metabolites and potential biomarkers for breast cancer development.

Material and methods

The data were extracted from large-scale genome-wide association study (GWAS) public databases. Instrumental variables were selected from a cohort study of 453 metabolic profiles from 7,824 participants. Breast cancer incidence data were obtained from a large cohort study involving 138,389 cases and 240,341 controls. Causal associations between human blood metabolites and breast cancer incidence were assessed using inverse-variance weighting, and MR-Egger regression.

Results

Five human blood

SUBMITTER: Liang G 

PROVIDER: S-EPMC11969560 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature