Identification of Alzheimer's disease biomarkers and their immune function characterization.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a neurodegenerative disease with neurogenic fiber tangles caused by amyloid-β protein plaques and tau protein hyperphosphorylation as the pathological manifestations. This study was based on multi-omics to investigate the mechanisms and immune characterization of AD.

Material and methods

Based on bulk RNA-seq (GSE122063 and GSE97760), we screened potential biomarkers for AD by differential expression analysis and machine learning algorithms. Then, we analyzed the expression characteristics and immune functions of the above biomarkers by scRNA-seq (single-cell RNA sequencing) data analysis (GSM4996463 and GSM4996462) and immune infiltration analysis.

Results

Five biomarkers (RBM3, GOLGA8A, ALS2, FSD2, and LOC100287628) were iden

SUBMITTER: Lin M 

PROVIDER: S-EPMC11969561 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature