Continuous Delivery of Hyperpolarized Xenon-129 Gas Using a "Stopped-Flow" Clinical-Scale Cryogen-Free Hyperpolarizer.

ABSTRACT: In 2022, the FDA approved hyperpolarized (HP) ¹²⁹Xe gas as an inhalable contrast agent for functional lung imaging. For clinical imaging, HP ¹²⁹Xe is usually given as a bolus inhalation. However, for preclinical applications (e.g., pulmonary imaging in small rodents), the continuous delivery of HP ¹²⁹Xe is greatly desired to enable MRI scanning under conditions of physiological continuous animal breathing patterns. Moreover, HP ¹²⁹Xe gas can be utilized for other applications including materials science and bioanalytical chemistry, where a continuous flow of hyperpolarized gas through an NMR sample over several minutes is also desired for sensing of ¹²⁹Xe inside an NMR spectrometer. ¹²⁹Xe is often hyperpolarized using contin

SUBMITTER: Chowdhury MRH 

PROVIDER: S-EPMC11969679 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature