Role of SMOC2 in adenomyosis: implications for ECM remodeling and EMT pathogenesis.

ABSTRACT:

Background

Adenomyosis is a common gynecological disorder characterized by the invasion of endometrial tissue into the myometrium, resulting in severe dysmenorrhea and menorrhagia. This study aimed to explore the role of SMOC2 (SPARC related modular calcium binding 2), an extracellular matrix (ECM) -associated protein, in the pathogenesis of adenomyosis and its potential as a therapeutic target.

Methods

We conducted a clinical study involving 35 patients diagnosed with adenomyosis and 30 controls. Ectopic endometrial tissue samples were collected and analyzed using immunohistochemistry (IHC), Masson staining, and cell culture techniques. The proliferative effect of SMOC2 on cells was evaluated using CCK- 8 assay, while the expression of SMOC2 and epithelial-mesenchymal trans

SUBMITTER: Wang LN 

PROVIDER: S-EPMC11969827 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature