Age-related dynamics of predominant methanogenic archaea in the human gut microbiome.

ABSTRACT:

Background

The reciprocal relationship between aging and alterations in the gut microbiota is a subject of ongoing research. While the role of bacteria in the gut microbiome is well-documented, specific changes in the composition of methanogens during extreme aging and the impact of high methane production in general on health remain unclear. This study was designed to explore the association of predominant methanogenic archaea within the human gut and aging.

Methods

Shotgun metagenomic data from the stool samples of young adults (n = 127, Age: 19-59 y), older adults (n = 86, Age: 60-99 y), and centenarians (n = 34, age: 100-109 years) were analyzed.

Results

Our findings reveal a compelling link between age and the prevalence of high methanogen phenotype, while overal

SUBMITTER: Mohammadzadeh R 

PROVIDER: S-EPMC11969853 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature