Design, synthesis, and SAR of antiproliferative activity of trioxatriangulene derivatives.

ABSTRACT: Trioxatriangulene (TOTA⁺) and its derivatives, which are primarily used as dyes in biological systems, have received considerable attention owing to their photophysical and electronic properties. Notably, their DNA-intercalating properties have been well established. Previous studies have identified TOTA⁺ derivatives, particularly ADOTA⁺ (R = -C₃H₇) and DAOTA⁺ (R = R' = -C₃H₇), as potent antiproliferative agents in triple-negative breast cancer (MDA-MB-231) and colorectal cancer (HCT-116) cell lines. However, the potential to enhance antiproliferative activity through different side chains prompted further investigation. In addition, partially cyclized tetramethoxyphenyl acridinium ion (TMPA⁺

SUBMITTER: Naiya MM 

PROVIDER: S-EPMC11969997 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature