Merging of Two Photoredox Cycles with One Perovskite Catalyst Achieving Dual Functionalization: N-Heterocyclization and Site-Selective Bromination of N-Arylamines.

ABSTRACT: Dual functionalization in organic synthesis represents a powerful strategy aimed at achieving multiple transformations within a single reaction cycle, thereby streamlining synthetic processes, enhancing efficiency, and imparting economic paths for complex molecules. Here, we report a heterogeneous perovskite nanocrystal (NC) photocatalytic system that can simultaneously drive two photoredox cycles in a single reaction. The dual process incorporates two distinct functional groups (N-heterocycles and bromines) into N-arylamines under the influence of a single catalyst (CsPbBr₃ NCs), allowing for the concurrent formation of two distinct architectures of 3-bromo-N-arylindoles. Mechanistically, long-lived charge separation and charge carrier accumulation at the NC surface enable pero

SUBMITTER: Mishra K 

PROVIDER: S-EPMC11970103 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature