Isoliquiritigenin Promotes the Repair of High Uric Acid-Induced Vascular Injuries.

ABSTRACT: Hyperuricemia (HUA) is a chronic metabolic disease mainly stemming from purine metabolism disorders and strongly correlated with cardiovascular diseases, gout, chronic kidney disease, and other diseases. Elevated levels of uric acid (UA) in serum will lead to vascular endothelial cell injuries directly, subsequently impairing normal functions of human blood vessels. Therefore, investigating endothelial cell injuries resulting from HUA and corresponding drug screening for its treatment are of great significance in the prevention and treatment of vascular diseases. Given the inherent advantages of multiple targets and pathways, we delved into the potential of traditional Chinese medicine in alleviating vascular injuries induced by HUA in detail. Through the establishment of an injury index l

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11970112 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature