Effects of statins on kidney function in older adults.

ABSTRACT:

Background

The effect of statin therapy on kidney function among older adults is unclear.

Objectives

To examine the association between statin use and changes in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR), positive or negative, in an older adult cohort with versus without chronic kidney disease (CKD) at baseline.

Methods

This analysis included 18,056 participants aged ≥65 years with versus without CKD at baseline in a randomized trial of low-dose aspirin, who had no prior cardiovascular events, major physical disability, or dementia initially. Outcome measures included eGFR and UACR. Linear mixed-effects models were used to estimate the associations of baseline statin use versus no use with eGFR and UACR changes over time.

SUBMITTER: Fravel MA 

PROVIDER: S-EPMC11970218 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature