Validation of Immune-Related Adverse Event (irAE) Case Definitions in a Real-World Lung Cancer Population.

ABSTRACT:

Background

The use of real-world data is increasing to examine immune-related adverse event (irAE) incidence and risk factors in immune checkpoint inhibitor (ICI) users. We aimed to validate five case definition algorithms for irAE in a Johns Hopkins lung cancer registry.

Methods

We conducted a retrospective cohort study using linked electronic health record (EHR) and cancer registry data from a large academic healthcare system. The Lung Immunotherapy irAE Monitoring Registry assesses irAEs in a group of patients treated for lung cancer at Johns Hopkins Medicine from 2013 to 2020. We used data from inpatient, outpatient, and emergency department encounters, including International Classification of Disease (ICD)-10 codes and medication administration records to classify the

SUBMITTER: Heyward JS 

PROVIDER: S-EPMC11970256 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature