Phased high-quality genome of the gymnosperm Himalayan Yew assists in paclitaxel pathway exploration.

ABSTRACT:

Background

Taxus wallichiana is an important species for paclitaxel production. Previous genome versions for Taxus spp. have been limited by extensive gaps, hindering the complete annotation and mining of paclitaxel (known as Taxol commercially) synthesis pathway-related genes.

Results

Here, we present the first phased high-quality reference genome of T. wallichiana, which significantly improves assembly quality and corrects large-scale assembly errors present in previous versions. The 2 haplotypes are 9.87 Gb and 9.98 Gb in length, respectively, and all 24 chromosomes were assembled with telomeres at both ends. Based on this high-quality genome (TWv1), we inferred that the candidate sex chromosome of T. wallichiana is chr12, and its sex determination system may follow a ZW

SUBMITTER: Li Z 

PROVIDER: S-EPMC11970372 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature