Mesenchymal stromal cell spheroids in sulfated alginate enhance muscle regeneration.

ABSTRACT: The therapeutic efficacy of mesenchymal stromal cells (MSCs) for tissue regeneration is critically linked to the potency of the complex mixture of growth factors, cytokines, exosomes, and other biological cues that they secrete. The duration of cell-based approaches is limited by rapid loss of cells upon implantation, motivating the need to prolong cell viability and extend the therapeutic influence of the secretome. We and others demonstrated that the secretome is upregulated when MSCs are formed into spheroids. Although the efficacy of the MSC secretome has been characterized in the literature, no studies have reported the therapeutic benefit of in situ sequestration of the secretome within a wound site using engineered biomaterials. We previously demonstrated the capacity of sulfated al

SUBMITTER: Gionet-Gonzales MA 

PROVIDER: S-EPMC11970561 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature