Long-term non-progression in children with HIV: estimates from international cohort data.

ABSTRACT:

Objectives

To estimate the probability of long-term nonprogression (LTNP) in the absence of antiretroviral treatment (ART) in children with perinatally acquired HIV, and the impact of LTNP definitions on these estimates.

Design

Analysis of longitudinal routine care data (follow-up to 2016) collected through a collaboration of cohorts of children in routine HIV care across Europe and Thailand.

Methods

LTNP was defined as reaching age 8 years without disease progression (defined as an AIDS diagnosis or immunosuppression based on WHO immunosuppression-for-age thresholds, age-adjusted CD4 +z -scores or CD4 + counts). ART initiation was treated as a competing risk (children initiating ART before age 8 were not considered to have LTNP). We included children born domesticall

SUBMITTER: Jackson C 

PROVIDER: S-EPMC11970603 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature