ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance.

ABSTRACT: The foodborne bacterium Listeria monocytogenes is transmitted to humans from various environmental sources through consumption of contaminated plant and animal-based food. L. monocytogenes uses ATP-binding cassette (ABC)-type drug transporters to resist antimicrobial compounds produced by competitors co-residing in its environmental reservoirs. We have shown previously that the TimAB transporter confers resistance of L. monocytogenes to tartrolon B, a boron containing macrodiolide produced by myxo- and proteobacterial species. Tartrolon B acts as a potassium ionophore and is sensed by TimR, the transcriptional repressor of timABR operon. We here have isolated tartrolon B resistant suppressor mutations outside the timABR locus. These mutations inactivated the clpP2 gene, which encodes the m

SUBMITTER: Engelgeh T 

PROVIDER: S-EPMC11970672 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature