Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation.

ABSTRACT:

Introduction

Hematological malignancies and allogeneic hematopoietic cell transplantation (alloHCT) often necessitate the use of opioids due to significant pain. This study aimed to investigate the impact of opioid use on the clinical outcomes of patients undergoing alloHCT.

Methods

A retrospective cohort study was conducted by merging data from our local transplant database with anonymized pharmacy records obtained from the Institute for Clinical Evaluative Sciences (ICES). We analyzed 681 patients who underwent alloHCT at Princess Margaret Cancer Centre between January 2010 and December 2019. Patients who initiated opioid use within one-year post-alloHCT and had opioid prescriptions for more than 30 days were categorized as intense opioid users (IOU). Additionally, patient

SUBMITTER: Alfaro Moya T 

PROVIDER: S-EPMC11970678 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature