Identification of IL-34 and Slc7al as potential key regulators in MASLD progression through epigenomic profiling.

ABSTRACT:

Objective

Epigenetic alterations are critical regulators in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the dynamic epigenomic landscapes are not well defined. Our previous study found that H3K27ac and H3K9me3 play important roles in regulating lipid metabolic pathways in the early stages of MASLD. However, the epigenomic status in the inflammation stages still needs to be determined.

Method

C57BL/6 male mice were fed with the methionine- and choline-deficient (MCD) or normal diet, and their serum and liver samples were collected after 6 weeks. Serum alanine aminotransferase (ALT), aspartate amino transferase (AST), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipopr

SUBMITTER: Zeng C 

PROVIDER: S-EPMC11970744 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature