Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability.

ABSTRACT:

Aim

To develop a glycerol modified liposomes to effectively deliver active agents into posterior segment of the eye for the management of posterior uveitis.

Materials and methods

The modified liposome enhanced with glycerol as an edge activator was fabricated using a 3² experimental design with independent variables being soya lecithin (mg) (X₁) and glycerol (%) (X₂) and vesicle size (nm) (Y₁), deformability index (%) (Y₂), and entrapment efficiency (%) (Y₃) as dependent variable with improve permeability and entrapment efficacy. These modified liposomes were then integrated into pHEMA-based contact lenses via free radical polymerization using different monomer mixture, co-polymer, crosslinker, and photo-initi

SUBMITTER: Dave J 

PROVIDER: S-EPMC11970793 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature