Genetically Predicted Causal Relationship between Gut Microbiota and Various Kidney Diseases.

ABSTRACT:

Introduction

Although recent research suggests that alterations in gut microbiota play a critical role in the pathophysiology of kidney diseases, the causal relationship between specific intestinal flora and the risk of kidney diseases remains unclear. Here, we investigated the causal relationship between gut microbiota and different kidney diseases through mendelian randomization analysis.

Methods

Gut microbiota and three types of kidney diseases, including diabetic nephropathy, IgA nephropathy, and membranous nephropathy, were identified from large-scale genome-wide association studies summary data. Inverse variance weighted method was employed to estimate causal relationships. Cochran's Q test was utilized to uncover any heterogeneity. The mendelian randomization-E

SUBMITTER: Chen ZJ 

PROVIDER: S-EPMC11970880 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature