Linalool combats <i>Saprolegnia parasitica</i> infections through direct killing of microbes and modulation of host immune system.

ABSTRACT: Saprolegnia parasitica is one of the most virulent oomycete species in freshwater aquatic environments, causing severe saprolegniasis and leading to significant economic losses in the aquaculture industry. Thus far, the prevention and control of saprolegniasis face a shortage of medications. Linalool, a natural antibiotic alternative found in various essential oils, exhibits promising antimicrobial activity against a wide range of pathogens. In this study, the specific role of linalool in protecting S. parasitica infection at both in vitro and in vivo levels was investigated. Linalool showed multifaceted anti-oomycetes potential by both of antimicrobial efficacy and immunomodulatory efficacy. For in vitro test, linalool exhibited strong anti-oomycetes activity and mode of act

SUBMITTER: Tang T 

PROVIDER: S-EPMC11970904 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature