Clinical characteristics and management of paroxysmal nocturnal haemoglobinuria in Latin America: a narrative review.

ABSTRACT: Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, complement-associated, haematological disorder. The level of knowledge about the disease and its management varies around the world. This narrative review provides an overview of available clinical data on PNH in Latin America (LATAM). A search of the PubMed, EMBASE and LILACS/IBECS databases to February 2023, and addition of author-known articles, yielded 24 relevant published articles, the majority (n = 15) from Brazil. Fourteen articles were full papers; 10 were conference abstracts. The prevalence of PNH in Brazil is estimated at 1:237,000 inhabitants. Among blood samples sent for flow cytometry screening for suspected PNH in Brazil and Colombia, 14 - 30% were positive. There is suggestion that disease subtypes may differ among LATA

SUBMITTER: Goldschmidt V 

PROVIDER: S-EPMC11971169 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature