Adsorption of Per- and Polyfluoroalkyl Substances by Edible Nutraceutical-Amended Montmorillonite Clays: In Vitro, In Vivo and In Silico Enterosorption Strategies.

ABSTRACT: Exposure of animals and humans to PFAS through contaminated water and foods pose significant threats to public health. To tackle this challenge, this study aimed to develop edible clays that might enhance the binding, detoxification, and elimination of PFAS in the gastrointestinal tract. Montmorillonite clays (CM) were amended with caffeine (CMCAF), curcumin (CMCUR), and riboflavin (CMRIB), and the binding efficacy for a mixture of four PFAS (PFOS, GenX, PFOA and PFBS) was determined. In vitro studies were used to explore adsorption isotherms while computational simulations investigate PFAS mixture, delineate the contribution of each PFAS molecule to clays and determine if amended clays can contribute to enhanced binding of different PFAS in the mixture. In vivo models (Lemna minor

SUBMITTER: Oladele JO 

PROVIDER: S-EPMC11971225 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature