Ex vivo cortical circuits learn to predict and spontaneously replay temporal patterns.

ABSTRACT: It has been proposed that prediction and timing are computational primitives of neocortical microcircuits, specifically, that neural mechanisms are in place to allow neocortical circuits to autonomously learn the temporal structure of external stimuli and generate internal predictions. To test this hypothesis, we trained cortical organotypic slices on two temporal patterns using dual-optical stimulation. After 24-h of training, whole-cell recordings revealed network dynamics consistent with training-specific timed prediction. Unexpectedly, there was replay of the learned temporal structure during spontaneous activity. Furthermore, some neurons exhibited timed prediction errors as revealed by larger responses when the expected stimulus was omitted compared to when it was present. Mechanisti

SUBMITTER: Liu B 

PROVIDER: S-EPMC11971321 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature