Dynamic monitoring of M-protein quantification by immunotyping using capillary zone electrophoresis during the chemotherapy of patients with multiple myeloma.

ABSTRACT: Dynamic quantification of monoclonal immunoglobulin proteins (M-proteins) by immunotyping using immunosubtraction (ISUB) through capillary zone electrophoresis (CZE) was performed to examine the efficacy of chemotherapy drugs in patients with multiple myeloma (MM). Twenty-one patients with eight different types of M-protein were analyzed, and M-protein quantification during chemotherapy regimens was dynamically monitored. For patients with M-protein identified by CZE, immunotyping by ISUB can accurately determine the percentage of M-protein. In this study, 15 of the 16 included patients with a definite diagnosis of MM were initially treated with bortezomib chemotherapy, and the treatment efficacy differed significantly among individuals. Three patients showed M-protein clearance, with the

SUBMITTER: Jia Z 

PROVIDER: S-EPMC11971346 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature