Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks.

ABSTRACT: The human brain exhibits a modular and hierarchical structure, spanning low-order sensorimotor to high-order cognitive/affective systems. What is the mechanistic significance of this organization for brain dynamics and information processing properties? We investigated this question using rare simultaneous multimodal electrophysiology (stereotactic and scalp electroencephalography - EEG) recordings in 36 patients with drug-resistant focal epilepsy during presurgical intracerebral electrical stimulation (iES) (323 stimulation sessions). Our analyses revealed an anatomical gradient of excitability across the cortex, with stronger iES-evoked EEG responses in high-order compared to low-order regions. Mathematical modeling further showed that this variation in excitability levels results from a

SUBMITTER: Momi D 

PROVIDER: S-EPMC11971347 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature