BMP2 expression in oral squamous cell carcinoma and its effects on SCC9 cell biological behavior.

ABSTRACT: This study examined bone morphogenetic protein 2 (BMP2) expression in oral squamous cell carcinoma (OSCC) and its effects on the biological behavior of OSCC cells, along with potential underlying mechanisms. BMP2 expression in OSCC was analyzed using mRNA data from The Cancer Genome Atlas and Genomics Expression Omnibus Database (GEO). SCC9 cells were transfected in vitro with small interfering RNA targeting BMP2 (si-BMP2), a negative control sequence (si-NC), BMP2 plasmid, or empty plasmid (vector). After transfection, Cell Counting Kit-8 assays, colony formation, scratch wound healing, Transwell, flow cytometry, quantitative reverse transcription polymerase chain reaction, and Western blot analyses were conducted to assess changes in SCC9 cell behavior in response to altered BMP2 express

SUBMITTER: Xing F 

PROVIDER: S-EPMC11971369 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature