Spatial and functional profiles distinguish target sets of Parkinson's disease and antipsychotic drugs with different clinical effects.

ABSTRACT: Several studies have examined the genetic factors shared between Parkinson's disease (PD) and schizophrenia (SZ), but the biological themes underlying their clinical relationships remain less explored. We employed systematic transcriptomic and network analyses to examine the genes targeted by two sets of antipsychotic drugs (APDs) - first-generation APDs inducing Parkinsonism and second-generation APDs typically effective against psychotic symptoms in PD - and two sets of PD drugs, one at risk of psychosis and the other with a lower risk of psychosis. Although global brain expression patterns did not effectively differentiate between the targets of the two sets of APDs, they did differentiate the targets of the two PD drug sets. However, both APD and PD target sets showed differences in me

SUBMITTER: Karunakaran KB 

PROVIDER: S-EPMC11971416 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature