PCL scaffold with well-defined hierarchical pores effectively controls cell migration and alignment of human mesenchymal stem cells.

ABSTRACT: With an increasing incidence of orthopedic fractures due to the growing aging population, the demand for novel bone tissue engineering treatments is rising. Existing biopolymeric scaffolds have hierarchical structure, are biocompatible, and are biodegradable, but struggle to control pore size and interconnectivity, essential features to regulate cell alignment and mechanobiological signaling. This highlights the need to design a biopolymeric scaffold with well-defined hierarchical structure and optimized surface properties to improve bone regeneration. To accomplish this, we proposed a grid-in-grid manufacturing approach and fabricated a solvent-free 3D polycaprolactone (PCL) scaffold with hierarchical pores using precision extruding deposition (PED) 3D printing technology. The fabricated

SUBMITTER: Lee SH 

PROVIDER: S-EPMC11971467 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature