A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-¹³C]pyruvate MRI.

ABSTRACT:

Purpose

In this work, we adopt the MR fingerprinting (MRF) framework and leverage its flexibility in quantitative pulse sequence design to propose improved balanced steady-state free precession (bSSFP)-based hyperpolarized Carbon-13 (¹³C) acquisitions for robust metabolic conversion rate quantification.

Methods

Spectrally selective bSSFP-based acquisitions with variable RF excitation were implemented for [1-¹³C]pyruvate and used in conjunction with prior implementation of [1-¹³C]lactate selective bSSFP imaging. MRF framework parameter estimation was performed using dictionary-based template matching. Influences of bSSFP-based acquisitions and sigmoid RF excitation scheme were assessed with simulation experiments and Monte Carlo evaluation. Me

SUBMITTER: Bennett Haller A 

PROVIDER: S-EPMC11971489 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature