Diffusion tensor subspace imaging of double diffusion-encoded MRI delineates small fibers and gray-matter microstructure not visible with single encoding techniques.

ABSTRACT:

Purpose

Double diffusion encoding (DDE) acquisition strategies promise specificity for small-dimensional structures inaccessible to single diffusion encoding (SDE). For DDE-weighted MRI scans to become relevant for whole brain imaging, signal reconstruction frameworks must accurately report microstructural features of interest-especially microscale anisotropy in complex tissue environments. This study examined the recently developed diffusion tensor subspace imaging (DiTSI) framework and its radial and spherical anisotropy metrics (RA and SA, respectively) in postmortem human brain tissue specimens.

Methods

MRI microscopy including multishell SDE-weighted and DDE-weighted imaging was performed for healthy brain stem and temporal lobe specimens and for specimens with Alzheime

SUBMITTER: Hutchinson EB 

PROVIDER: S-EPMC11971496 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature