Enhanced detection of glutamate via transverse relaxation encoding with narrowband decoupling in the human brain.

ABSTRACT:

Purpose

This study aims to improve the detection of glutamate (Glu) concentration and T₂ using an enhanced transverse relaxation encoding with narrowband decoupling (TREND) technique.

Methods

A new editing pulse was designed to simultaneously invert both Glu H3 spins (2.12 ppm and 2.05 ppm) while minimizing the excitation of Glu H4. Additionally, a frequency band was created to invert the lactate (Lac) H2 spin (4.10 ppm) while saturating the NAA aspartyl H2 spin (4.38 ppm). Numerical simulations compared Glu and Lac signals using the original and new editing pulses. In vivo experiments were conducted on healthy participants at 7 T to validate this enhanced TREND technique.

Results

Numerical simulations showed prominently enhanced Glu and Lac resonance signa

SUBMITTER: An L 

PROVIDER: S-EPMC11971497 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature