Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on K trans and PS.

ABSTRACT:

Purpose

Focused ultrasound-induced blood-brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard for quantifying induced BBB permeability is the Ktrans$$ {K}^{\mathrm{trans}} $$ parameter, which reflects both permeability and plasma flow. The influence of plasma flow can be eliminated by estimating the PS parameter. However, this parameter has been largely unexplored in this application. This study aims to compare permeability estimates based on Ktrans$$ {K}^{\mathrm{trans}} $$ and PS in focused ultrasound-induced BBB opening experiments.

Methods

We used the extended Tofts model (ETM) and the two-compartment exchange model (2CXM) to estimate Ktrans$$ {K}^{\mathrm{trans}} $$ and PS parameters, respectively. Permeability estimates were com

SUBMITTER: Hyvlova D 

PROVIDER: S-EPMC11971499 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature