Reactive Pleocytosis After Repeated Lumbar Puncture-Implications for Clinical Practice.

ABSTRACT:

Introduction

Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear.

Objective

To investigate whether repeated LP is associated with reactive pleocytosis and disruption of blood-CSF barrier function and to determine the role of interval between repeated LP.

Methods

Patients with non-inflammatory neurological disease (NIND) and at least two consecutive LP were included. Longitudinal changes in CSF white blood cell count (WBC), CSF total protein (TP), and CSF/serum albumin quotient (Q_alb) were assessed depending on the time interval between the LP.

Results

A total of 73 patients with a median age

SUBMITTER: Schmidauer M 

PROVIDER: S-EPMC11971533 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature