Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers.

ABSTRACT:

Importance

Blood phosphorylated tau 217 (p-tau217) showed good performance in predicting brain amyloidosis. However, the importance of detailed cognitive phenotyping in patients without dementia when interpreting p-tau217 results remains unclear.

Objective

To assess whether accuracy, negative predictive value (NPV), and positive predictive value (PPV) in predicting brain amyloidosis using p-tau217 varies across clinical presentations in patients without dementia.

Design, setting, and participants

The study design included 2 observational, prospective cohort studies: The Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders (MEMENTO), with enrollment from 2011 to 2014 and 5 years of follow-u

SUBMITTER: Bouteloup V 

PROVIDER: S-EPMC11971688 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature