Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model.

ABSTRACT:

Objective

The objective of this study was to use a novel combined pharmacoepidemiologic and amyotrophic lateral sclerosis (ALS) mouse model approach to identify potential motor neuron protective medications.

Methods

We constructed a large, population-based case-control study to investigate motor neuron disease (MND) among US Medicare beneficiaries aged 66 to 90 in 2009. We included 1,128 incident MND cases and 56,400 age, sex, race, and ethnicity matched controls. We calculated MND relative risk for >1,000 active ingredients represented in Part D (pharmacy) claims in 2006 to 2007 (>1 year before diagnosis/reference). We then applied a comprehensive screening approach to select medications for testing in SOD1^G93A mice: sulfasalazine, telmisartan, and lovastatin. We

SUBMITTER: Kreple CJ 

PROVIDER: S-EPMC11971731 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature