Clostridioides difficile concentration-dependant alterations in gut microbiota of asymptomatic infants.

ABSTRACT:

Background

Asymptomatic carriage of Clostridioides difficile is highly prevalent in early infancy, affecting approximately 40% of infants. This phenomenon offers a unique opportunity to study its impact on the gut microbiota without the confounding effects of disease. In this study, we analysed C. difficile-associated gut microbiome alterations in 76 asymptomatic infants, one year after receiving antibiotic treatment during early infancy. The presence and concentration of C. difficile were assessed in relation to gut microbiota structure and an extensive set of metadata.

Results

Bacterial gut community structure was characterized using 16 S rRNA amplicon sequencing, while C. difficile concentration and the presence of the tcdB gene were quantified via digital PCR. C. diffici

SUBMITTER: Mahnic A 

PROVIDER: S-EPMC11971792 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature