Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD), a globally prevalent neurodegenerative disorder, has been implicated with oxidative stress (OS) as a central pathomechanism. Excessive reactive oxygen species (ROS) trigger neuronal damage and may induce disulfidptosis-a novel cell death modality not yet characterized in PD pathogenesis.

Method

Integrated bioinformatics analyses were conducted using GEO datasets to identify PD-associated differentially expressed genes (DEGs). These datasets were subjected to: immune infiltration analysis, gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), intersection analysis of oxidative stress-related genes (ORGs) and disulfidptosis-related genes (DRGs) for functional enrichment annotation. Following hub gene ide

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11971801 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature