Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes.

ABSTRACT:

Background

Epigenetic modifications provide mechanisms for influencing gene expression, regulating cell differentiation and maintaining long-term memory of cellular identity and function. As oocytes transmit epigenetic information to offspring, correct establishment of the oocyte epigenome is important for normal offspring development. Oocyte epigenetic programming is highly complex, involving a range of epigenetic modifiers which interact to establish a specific distribution of DNA methylation and histone modifications. Disruptions to oocyte epigenetic programming can alter epigenetic memory and prevent normal developmental outcomes in the next generation. Therefore, it is critical that we further our understanding of the interdependent relationships between various epigenetic mod

SUBMITTER: Edwards-Lee CA 

PROVIDER: S-EPMC11971813 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature