Ginger extract inhibits c-MET activation and suppresses osteosarcoma in vitro and in vivo.

ABSTRACT:

Background

Osteosarcoma (OS) as an invasive and lethal malignancy showing a low 5-year survival rate requires novel therapeutic targets and their suppressors to improve prevention and treatment strategies.

Methods

Our research served to clarify the therapeutic potential of ginger extract and its underlying antineoplastic mechanisms in OS. In vitro studies were used to detect the anti-proliferation ability of ginger extract towards OS cells. Patient-derived xenograft (PDX) was performed to confirm whether ginger extract suppressed tumor growth. Cancer Heat Shock Protein (HSP) database was utilized to identify the potential target of ginger extract, which was subsequently validated through a computational docking model screening method, molecular dynamics simulations and pull-

SUBMITTER: Yanzhang R 

PROVIDER: S-EPMC11971884 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature