Two routes for tyrosol production by metabolic engineering of Corynebacterium glutamicum.

ABSTRACT:

Background

The phenolic compound tyrosol is widely used in the pharmaceutical industry, owing to its beneficial effects on human health and its use as a precursor for key pharmaceuticals, including β₁-receptor blockers. Tyrosol can be found in olive oil, but despite its natural biosynthesis in plants, low extraction efficiencies render microbial production a more viable alternative.

Results

Here, we engineered the L-tyrosine overproducing Corynebacterium glutamicum strain AROM3 for the de novo production of tyrosol. Two routes were established and compared: one via 4-OH-phenylpyruvate as intermediate and the other via tyramine. We initially expected the first route to require heterologous expression of a prephenate dehydrogenase gene, given that C. glutamicum lack

SUBMITTER: Junker N 

PROVIDER: S-EPMC11971909 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature