Polygenic Risk and Coronary Artery Disease Severity.

ABSTRACT:

Background

Coronary atherosclerotic burden and adverse coronary heart disease events are related phenotypes with likely shared genetic cause.

Methods

We analyzed 6021 patients with available coronary angiography, genotyping, and exome sequencing data. We tested for associations of polygenic risk scores for coronary heart disease (PRS_CHD) with multiple measures of coronary artery disease (CAD) severity. We assessed the joint associations of PRS_CHD and pathogenic/likely pathogenic variants in 3 familial hypercholesterolemia genes, with CAD severity. We performed mediation analyses to explore whether CAD severity mediated the association of PRS_CHD with prevalent coronary heart disease and incident myocardial infarction.

Results

A 1-SD inc

SUBMITTER: Sherafati A 

PROVIDER: S-EPMC11971913 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature