In vivo dosimetry for proton therapy: A Monte Carlo study of the Gadolinium spectral response throughout the course of treatment.

ABSTRACT:

Background

In proton radiotherapy, the steep dose deposition profile near the end of the proton's track, the Bragg peak, ensures a more conformed deposition of dose to the tumor region when compared with conventional radiotherapy while reducing the probability of normal tissue complications. However, uncertainties, as in the proton range, patient geometry, and positioning pose challenges to the precise and secure delivery of the treatment plan (TP). In vivo range determination and dose distribution are pivotal for mitigation of uncertainties, opening the possibility to reduce uncertainty margins and for adaptation of the TP.

Purpose

This study aims to explore the feasibility of utilizing gadolinium (Gd), a highly used contrast agent in MRI, as a surrogate for in vivo dosimet

SUBMITTER: Bras M 

PROVIDER: S-EPMC11972047 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature