Synthetic Challenges toward Modeling Formate Dehydrogenases Using [W^VI≡S] Complexes Supported by a Tetradentate [N₂S₂]^4- Ligand.

ABSTRACT: This report documents our attempts at synthesizing a terminal [W^VI≡S] complex supported by a tetradentate, diamido/dithiolate ligand ([N₂S₂]^4-). The target compound was selected because it would serve as a synthetic model for the active sites of formate dehydrogenase (FDH) enzymes. Although the desired [N₂S₂]W^VI≡S species was observed as an NEt₃ adduct by mass spectrometry in one case, generally unwanted side reactions prevented isolation and definitive characterization of the target compound. Instead, isolated products characterized by X-ray crystallography included {[N₂S₂]H}W^VI(S₂)Cl from redox chemistry of the terminal sulfide, ([N₂S₂]

SUBMITTER: Basu D 

PROVIDER: S-EPMC11972111 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature